Librería Servicio Médico

Author : Hiraku / Kawanishi / Ohshima

Language: English

Finishing : Hardcover, 400 pages

ISBN : 978-1-118-16030-5

Edition Number: 2014

Author Information:

YUSUKE HIRAKU is an Assistant Professor and Research Professor of the Department of Environmental and Molecular Medicine at Mie University. In 2009, he received the Young Investigator Award from the Japanese Society for Hygiene for his work on inflammation-related carcinogenesis.

SHOSUKE KAWANISHI is a Dean and Professor of the Faculty of Pharmaceutical Sciences at Suzuka University of Medical Science. He received the Congress Award of the Japanese Society for Hygiene in 2001, the SFRR Japan Prize in 2006, and the Congress Award of the Japanese Environmental Mutagen Society in 2009.

HIROSHI OHSHIMA was a Scientist and Chief of the Unit of Endogenous Cancer Risk Factors at the International Agency for Research on Cancer and is currently a Professor of the School of Food and Nutritional Sciences at the University of Shizuoka. His main research interest is the role of nutritional factors in the causation of human chronic diseases.

Description:

A new perspective on the link between inflammation and cancer

Inflammation is the human body’s normal biological response to threats in the modern world, as well as a defense against the harmful influence of pathogens, the environment, and poor nutrition. But what happens when the inflammatory response is triggered repeatedly and sustained for long periods of time? Cancer and Inflammation Mechanisms: Chemical, Biological, and Clinical Aspects discusses the mechanisms by which chronic inflammation can lead to cancer, the various causative agents, and possible prevention methods.

A compilation of the latest information coming out of the various fields of cancer research, this book provides a detailed look at inflammation-related carcinogenesis from the perspective of researchers at the forefront of the field. It takes an interdisciplinary approach to the topic, and provides comprehensive information about the major factors at work in inflammation, cancer, and the intersection of the two conditions. Topics include:

• A general overview of inflammation-related cancer
• The biochemistry of inflammation and its effects on DNA
• Molecular biology and the role of microRNA in carcinogenesis
• Specific causative agents including oncogenic viruses, asbestos, and nanomaterial
• Anti-inflammatories, nutraceuticals, and other preventative measures

A deeper understanding of the mechanisms behind inflammation-related carcinogenesis can lead to better patient outcomes by improving diagnostics and prevention, as well as altering the approach to treatment. Cancer and Inflammation Mechanisms: Chemical, Biological, and Clinical Aspects provides the knowledge base researchers need to push the field forward.

Table Of Contents:

• CONTRIBUTORS ix
• PREFACE xv
• SECTION I GENERAL OVERVIEW OF INFLAMMATION-RELATED CANCER 
• CHAPTER 1 INFECTION, INFLAMMATION, AND CANCER: OVERVIEW 1
• Hiroshi Ohshima, Noriyuki Miyoshi, and Susumu Tomono
• CHAPTER 2 STEM CELL THEORY AND INFLAMMATION-RELATED CANCER 9
• Toshihiko Tanno and William Matsui
• CHAPTER 3 EPITHELIAL–MESENCHYMAL TRANSITION: A LINK BETWEEN CANCER AND INFLAMMATION 23
• Jonas Fuxe and Mikael C. I. Karlsson
• SECTION II BIOCHEMISTRY IN INFLAMMATION-RELATED CANCER
• CHAPTER 4 ROLE OF NITRATIVE DNA DAMAGE IN INFLAMMATION RELATED CARCINOGENESIS 41
• Yusuke Hiraku and Shosuke Kawanishi
• CHAPTER 5 LIPID PEROXIDATION–DERIVED DNA ADDUCTS AND THE ROLE IN INFLAMMATION-RELATED CARCINOGENESIS 61
• Helmut Bartsch and Urmila Jagadeesan Nair
• CHAPTER 6 LEVEL OF INFLAMMATION-RELATED DNA ADDUCTS IN HUMAN TISSUES 75
• Tomonari Matsuda, Pei-Hsin Chou, and Haruhiko Sugimura
• SECTION III MOLECULAR BIOLOGY IN INFLAMMATION-RELATED CANCER
• CHAPTER 7 TOLL-LIKE RECEPTORS: ROLE IN INFLAMMATION AND CANCER 83
• Sarang Tartey and Osamu Takeuchi
• CHAPTER 8 INFLAMMASOMES AND INFLAMMATION 103
• Kaiwen W. Chen, Ayanthi A. Richards, Alina Zamoshnikova, and Kate Schroder
• CHAPTER 9 ACTIVATION-INDUCED CYTIDINE DEAMINASE: AN INTRINSIC GENOME MODULATOR IN INFLAMMATION-ASSOCIATED CANCER DEVELOPMENT 119
• Hiroyuki Marusawa and Tsutomu Chiba
• CHAPTER 10 MicroRNA AND INFLAMMATION-RELATED CANCER 131
• Zhaojian Gong, Zhaoyang Zeng, Pranab Behari Mazumder, Jian Ma, Ming Zhou, Xiayu Li, Xiaoling Li, Wei Xiong, Yong Li, and Guiyuan Li
• CHAPTER 11 INFLAMMATION AS A NICHE FOR TUMOR PROGRESSION 149
• Futoshi Okada
• SECTION IV INFLAMMATION-RELATED CANCER INDUCED BY SPECIFIC CAUSES
• CHAPTER 12 HUMAN PAPILLOMAVIRUS AND CERVICAL CANCER 165
• Kurt J. Sales
• CHAPTER 13 HEPATITIS VIRUSES AND HEPATOCELLULAR CARCINOMA 181
• Wai-Kay Seto, Ching-Lung Lai, and Man-Fung Yuen
• CHAPTER 14 EPSTEIN–BARR VIRUS AND NASOPHARYNGEAL CARCINOMA 193
• Xiaoying Zhou, Xue Xiao, Fu Chen, Tingting Huang, and Zhe Zhang
• CHAPTER 15 BARRETT’S ESOPHAGUS AND ESOPHAGEAL CANCER 213
• Albert Roessner and Angela Poehlmann
• CHAPTER 16 ASBESTOS-INDUCED CHRONIC INFLAMMATION AND CANCER 223
• Andrea Napolitano, Sandro Jube, Giovanni Gaudino, Harvey I. Pass, Michele Carbone, and Haining Yang
• CHAPTER 17 NANOMATERIALS 235
• Yiqun Mo, Rong Wan, David J. Tollerud, and Qunwei Zhang
• CHAPTER 18 INFLAMMATORY PATHWAYS OF RADIATION-INDUCED TISSUE INJURY 249
• Danae A. Laskaratou, Ifigeneia V. Mavragani, and Alexandros G. Georgakilas
• CHAPTER 19 PHOTOCARCINOGENESIS AND INFLAMMATION 271
• Chikako Nishigori
• SECTION V. PREVENTION OF INFLAMMATION-RELATED CARCINOGENESIS
• CHAPTER 20 CHEMOPREVENTION OF COLORECTAL CANCER BY ANTI-INFLAMMATORY AGENTS 285
• Michihiro Mutoh, Mami Takahashi, and Keiji Wakabayashi
• CHAPTER 21 NUTRACEUTICALS AND COLON CANCER PREVENTION 301
• Deepak Poudyal and Lorne J. Hofseth
• CHAPTER 22 CANCER CHEMOPREVENTION BY TARGETING COX-2 USING DIETARY PHYTOCHEMICALS 339
• Kyung-Soo Chun and Young-Joon Surh
• CHAPTER 23 REGULATION OF INFLAMMATION-ASSOCIATED INTESTINAL DISEASES WITH PHYTOCHEMICALS 355
• Akira Murakami
• INDEX 371

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