Librería Servicio Médico

Author : Jorg Knablein

Language: English

Finishing : Hardcover, 800 pages

ISBN : 978-3-527-32283-1

Edition Number: 2013

Author Information:

Dr. Jörg Knäblein studied Biotechnology / Chemical Engineering at the Society for Biotechnology Research (GBF) in Braunschweig, Germany and Biochemistry at the Max-Planck-Institute for Biochemistry. He received his Ph.D. from the Max-Planck-Institute for Biochemistry in Martinsried / Munich where he worked in the group of Professor Robert Huber (Nobelprize laureate in 1988). Jörg Knäblein holds a leading position in technology scouting at Bayer Schering Pharma AG, Berlin.

Description:

This collection of high-profile contributions provides a unique insight into the development of novel, successful biopharmaceuticals.

Outstanding authors, including Nobel laureate Robert Huber as well as prominent company researchers and CEOs, present valuable insider knowledge, limiting their scope to those procedures and developments with proven potential for the biotechnology industry. They cover all relevant aspects, from the establishment of biotechnology parks, the development of successful compounds and the implementation of efficient manufacturing processes, right up to the establishment of advanced delivery routes.

Table Of Contents:

• Members of the Working Group for Excavations V
• Preface VII
• Notes for the User XI
• 1 Introduction 1
• 1.1 Engineering prerequisites for applying the Recommendations (R l) 1
• 1.2 Governing regulations (R 76) 1
• 1.3 Safety factor approach (R 77) 4
• 1.4 Limit states (R 78) 6
• 1.5 Support of retaining walls (R 67) 9
• 1.6 Planning and examination of excavations (R 106) 10
• 2 Analysis principles 11
• 2.1 Actions (R 24) 11
• 2.2 Determination of soil properties (R 2) 13
• 2.3 Earth pressure angle (R 89) 15
• 2.4 Partial safety factors (R 79) 17
• 2.5 General requirements for adopting live loads (R 3) 18
• 2.6 Live loads from road and rail traffic (R 55) 20
• 2.7 Live loads from site traffic and site operations (R 56) 23
• 2.8 Live loads from excavators and lifting equipment (R 57) 24
• 3 Magnitude and distribution of earth pressure 29
• 3.1 Magnitude of earth pressure as a function of the selected construction method (R 8) 29
• 3.2 Magnitude of total active earth pressure lead without surcharge loads (R 4) 30
• 3.3 Distribution of active earth pressure without surcharges (R 5) 34
• 3.4 Magnitude of total active earth pressure lead from live loads (R 6) 37
• 3.5 Distribution of active earth pressure from live loads (R 7) 39
• 3.6 Superimposing earth pressure components with surcharges (R 71) 42
• 3.7 Determination of at-rest earth pressure (R 18) 44
• 3.8 Earth pressure in retreating states (R 68) 46
• 4 General stipulations for analysis 49
• 4.1 Stability analysis (R 81) 49
• 4.2 General information on analysis methods (R 11) 51
• 4.3 Determination and analysis of embedment depth (R 80) 54
• 4.4 Determination of action effects (R 82) 58
• 4.5 Modulus of subgrade reaction method (R 102) 61
• 4.6 Finite-element method (R 103) 66
• 4.7 Analysis of the vertical component of the mobilized passive earth pressure (R 9) 71
• 4.8 Analysis of the transfer of vertical forces into the subsurface (R 84) 73
• 4.9 Stability analyses for braced excavations in special cases (R 10) 76
• 4.10 Serviceability analysis (R 83) 78
• 4.11 Allowable simplifications in limit states GEO 2 or STR (R 104) 82
• 5 Analysis approaches for soldier pile walls 85
• 5.1 Determination of load models for soldier pile walls (R 12) 85
• 5.2 Pressure diagrams for supported soldier pile walls (R 69) 87
• 5.3 Soil reactions and passive earth pressure for soldier pile walls with free earth supports (R 14) 89
• 5.4 Fixed earth support for soldier pile walls (R 25) 91
• 5.5 Equilibrium of horizontal forces for soldier pile walls (R 15) 94
• 6 Analysis approaches for sheet pile walls and in-situ concrete walls 99
• 6.1 Determination of load models for sheet pile walls and in-situ concrete walls (R 16)99
• 6.2 Pressure diagrams for supported sheet pile walls and in-situ concrete walls (R 70)101
• 6.3 Ground reactions and passive earth pressure for sheet pile walls and in-situ concrete walls with free earth support 
• (R 19) 103
• 6.4 Fixed earth support for sheet pile walls and in-situ concrete walls (R 26) 106
• 7 Anchored retaining walls 111
• 7.1 Magnitude and distribution of earth pressure for anchored retaining walls (R 42) 111
• 7.2 Analysis of force transfer from anchors to the ground (R 43) 112
• 7.3 Verification of stability at the lower failure plane (R 44) 113
• 7.4 Analysis of overall stability (R 45) 119
• 7.5 Measures to counteract deflections in anchored retaining walls (R 46) 122
• 8 Excavations with special ground plans 125
• 8.1 Excavations with circular plan (R 73) 125
• 8.2 Excavations with oval plan (R 74) 130
• 8.3 Excavations with rectangular plan (R 75) 137
• 9 Excavations adjacent to structures 143
• 9.1 Engineering measures for excavations adjacent to structures (R 20) 143
• 9.2 Analysis of retaining walls with active earth pressure for excavations adjacent to structures (R 21) 145
• 9.3 Active earth pressure for large distances to structures (R 28) 147
• 9.4 Active earth pressure for small distances to structures (R 29) 149
• 9.5 Analysis of retaining walls with increased active earth pressure (R 22) 151
• 9.6 Analysis of retaining walls with at-rest earth pressure (R 23) 155
• 9.7 Mutual influence of opposing retaining walls for excavations adjacent to structures (R 30) 159
• 10 Excavations in water 163
• 10.1 General remarks on excavations in water (R 58) 163
• 10.2 Flow forces (R 59) 165
• 10.3 Dewatered excavations (R 60) 166
• 10.4 Analysis of hydraulic heave safety (R 61) 168
• 10.5 Analysis of buoyancy safety (R 62) 172
• 10.6 Stability analysis of retaining walls in water (R 63) 179
• 10.7 Design and construction of excavations in water (R 64) 183
• 10.8 Water management (R 65) 186
• 10.9 Monitoring excavations in water (R 66) 188
• 11 Excavations in unstable rock mass 189
• 11.1 General recommendations for excavation in unstable rock mass (R 38) 189
• 11.2 Magnitude of rock mass pressure (R 39) 192
• 11.3 Distribution of rock pressure (R 40) 194
• 11.4 Bearing capacity of rock mass for support forces at the embedment depth (R 41) 195
• 12 Excavations in soft soils 197
• 12.1 Scope of Recommendations R 91 to R 101 (R 90) 197
• 12.2 Slopes in soft soils (R 91) 198
• 12.3 Wall types in soft soils (R 92) 200
• 12.4 Construction procedure in soft soils (R 93) 204
• 12.5 Shear strength of soft soils (R 94) 208
• 12.6 Earth pressure on retaining walls in soft soils (R 95) 213
• 12.7 Ground reactions for retaining walls in soft soils (R 96) 217
• 12.8 Water pressure in soft soils (R 97) 222
• 12.9 Determination of embedment depths and action effects for excavations in soft soils (R 98) 228
• 12.10 Additional stability analyses for excavations in soft soils (R 99) 230
• 12.11 Water management for excavations in soft soils (R 100) 234
• 12.12 Serviceability of excavation structures in soft soils (R 101) 235
• 13 Analysis of the bearing capacity of structural elements 239
• 13.1 Material parameters and partial safety factors for structural element resistances (R 88) 239
• 13.2 Bearing capacity of soldier pile infilling (R 47) 240
• 13.3 Bearing capacity of soldier piles (R 48) 243
• 13.4 Bearing capacity of sheet piles (R 49) 246
• 13.5 Bearing capacity of in-situ concrete walls (R 50) 248
• 13.6 Bearing capacity of waling (R 51) 250
• 13.7 Bearing capacity of struts (R 52) 251
• 13.8 Bearing capacity of trench lining (R 53) 254
• 13.9 Bearing capacity of provisional bridges and excavation covers (R 54) 255
• 13.10 External bearing capacity of soldier piles, sheet pile walls and in-situ concrete walls (R 85) 257
• 13.11 Bearing capacity of tension piles and ground anchors (R 86) 259
• 14 Measurements and monitoring on excavation structures 261
• 14.1 Purpose of measurements and monitoring (R 31) 261
• 14.2 Measurands and measuring methods (R 32) 262
• 14.3 Measurement planning (R 33) 264
• 14.4 Location of measuring points (R 34) 266
• 14.5 Carrying out measurements and forwarding measurement results (R 35) 267
• 14.6 Evaluation and documentation of measurement results (R 36) 268
• Annex 271
• Bibliography 287
• Terms and notation 299
• Recommendations in numerical order 303

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