Librería Servicio Médico

Author : Mitra / H. Lee / Cheng

Language: English

Finishing : Hardcover, 550 pages

ISBN : 978-1-118-02266-5

Edition Number: 2013

Author Information:

ASHIM K. MITRA, PhD, is Chairman of Pharmaceutical Sciences at the University of Missouri-Kansas City. Dr. Mitra is also a University of Missouri Curators' Professor and has more than thirty years of experience in the field of ocular drug delivery and disposition. He has been the recipient of research awards from the NIH, AAPS, AACP, ARVO, and other pharmaceutical organizations.

CHI H. LEE, PhD, is Professor of Pharmaceutical Sciences at the University of Missouri-Kansas City, where he teaches undergraduate and graduate pharmacy courses. His research focuses on elucidation of pathological mechanisms and formulation development of microbicidal and cardiovascular devices.

KUN CHENG, PhD, is Associate Professor of Pharmaceutical Sciences at the University of Missouri-Kansas City. His research seeks to develop novel drug delivery systems for siRNA and small molecule drugs. Dr. Cheng is the recipient of the 2011 American Association of Pharmaceutical Scientists (AAPS) New Investigator Grant Award in Pharmaceutics and Pharmaceutical Technologies.

Description:

Provides both fundamentals and new and emerging applications

Advanced Drug Delivery brings readers fully up to date with the state of the science, presenting the basics, formulation strategies, and therapeutic applications of advanced drug delivery. The book demonstrates how core concepts of pharmaceutical sciences, chemistry, and molecular biology can be combined and applied in order to spark novel ideas to design and develop advanced drug delivery systems for the treatment of a broad range of human diseases.

Advanced Drug Delivery features contributions from an international team of pharmaceutical scientists. Chapters reflect a thorough review and analysis of the literature as well as the authors' firsthand experience developing drug delivery systems. The book is divided into four parts:

• Part I, Introduction and Basics of Advanced Drug Delivery, explores physiological barriers, stability, transporters, and biomaterials in drug delivery
• Part II, Strategies for Advanced Drug Delivery, offers tested and proven strategies for advanced delivery of both small molecules and macromolecules
• Part III, Translational Research of Advanced Drug Delivery, focuses on regulatory considerations and translational applications of advanced drug delivery systems for the treatment of cardiovascular diseases, cancer, sexually transmitted diseases, ophthalmic diseases, and brain diseases
• Part IV, Future Applications of Advanced Drug Delivery in Emerging Research Areas, examines stem cell research, cell-based therapeutics, tissue engineering, and molecular imaging

Each chapter provides objectives and assessment questions to help readers grasp key concepts and assess their knowledge as they progress through the book.

Advanced Drug Delivery is recommended for graduates and upper-level undergraduates in the pharmaceutical sciences who need a solid foundation in the basics. It is also recommended for pharmaceutical professionals who want to take advantage of new and emerging applications in advanced drug delivery systems.

Table Of Contents:

• PREFACE xi
• ABOUT THE AUTHORS xiii
• CONTRIBUTORS xv
• PART I INTRODUCTION AND BASICS OF ADVANCED DRUG DELIVERY 1
• 1 Physiological Barriers in Advanced Drug Delivery: Gastrointestinal Barrier 3
• D. Alexander Oh and Chi H. Lee
• 2 Solubility and Stability Aspects in Advanced Drug Delivery 21
• Hoo-Kyun Choi, Robhash K. Subedi, and Chi H. Lee
• 3 The Role of Transporters and the Efflux System in Drug Delivery 47
• Varun Khurana, Dhananjay Pal, Mukul Minocha, and Ashim K. Mitra
• 4 Biomaterial in Advanced Drug Delivery 75
• Megha Barot, Mitesh Patel, Xiaoyan Yang, Wuchen Wang, and Chi H. Lee
• PART II STRATEGIES FOR ADVANCED DRUG DELIVERY 103
• 5 Strategies of Drug Targeting 105
• Ravi S. Shukla, Zhijin Chen, and Kun Cheng
• 6 Prodrug and Bioconjugation 123
• Ramya Krishna Vadlapatla, Sujay Shah, Aswani Dutt Vadlapudi, and Ashim K. Mitra
• 7 Nanoscale Drug Delivery Systems 141
• Mitan R. Gokulgandhi, Ashaben Patel, Kishore Cholkar, Megha Barot, and Ashim K. Mitra
• 8 Stimuli-Responsive Target Strategies 157
• Chi H. Lee
• 9 Implants 183
• Aswani Dutt Vadlapudi, Ashaben Patel, Ramya Krishna Vadlapatla, Durga Paturi, and Ashim K. Mitra
• 10 Aptamers in Advanced Drug Delivery 201
• Weiwei Gao, Omid C. Farokhzad, and Nazila Kamaly
• 11 Nanofiber 219
• Megha Barot, Mitan R. Gokulgandhi, Animikh Ray, and Ashim K. Mitra
• 12 Biomimetic Self-Assembling Nanoparticles 231
• Maxim G. Ryadnov
• 13 Protein and Peptide Drug Delivery 241
• Mitesh Patel, Megha Barot, Jwala Renukuntla, and Ashim K. Mitra
• 14 Delivery of Nucleic Acids 257
• Shaoying Wang, Bin Qin, and Kun Cheng
• 15 Delivery of Vaccines 275
• Hari R. Desu, Rubi Mahato, and Laura A. Thoma
• PART III TRANSLATIONAL RESEARCH OF ADVANCED DRUG DELIVERY 297
• 16 Regulatory Considerations and Clinical Issues in Advanced Drug Delivery 299
• Mei-Ling Chen
• 17 Advanced Drug Delivery in Cancer Therapy 323
• Wanyi Tai and Kun Cheng
• 18 Advanced Delivery in Cardiovascular Diseases 341
• Gayathri Acharya, Wuchen Wang, Divya Teja Vavilala, Mridul Mukherji, and Chi H. Lee
• 19 Recent Advances in Ocular Drug Delivery 365
• Varun Khurana, Deep Kwatra, Vibhuti Agrahari, and Ashim K. Mitra
• 20 Advanced Drug Delivery Against STD 381
• Chi H. Lee
• 21 Advanced Drug Delivery to the Brain 405
• Nanda K. Mandava, Mitesh Patel, and Ashim K. Mitra
• PART IV FUTURE APPLICATIONS OF ADVANCED DRUG DELIVERY IN EMERGING RESEARCH AREAS 423
• 22 Cell-Based Therapeutics 425
• Zhaoyang Ye, Yan Zhou, Haibo Cai, and Wen-Song Tan
• 23 Biomedical Applications and Tissue Engineering of Collagen 445
• Chi H. Lee and Yugyung Lee
• 24 Molecular Imaging of Drug Delivery 469
• Zheng-Rong Lu
• ANSWERS 489
• INDEX 511

Valoración:

¡Sea el primero en dejar un comentario!

Nuevo Comentario