Librería Servicio Médico

Author : Michael Wolfe / C. Lowe

Language: English

Finishing : Paperback, 288 pages

ISBN : 978-1-118-48157-8

Edition Number: 2014

Description:

Learn all you need to know about gastrointestinal drugs and their clinical use with this one-stop, rapid reference pocket guide.

Brought to you by many of the world's leading GI drug experts, Pocket Guide to Gastrointestinal Drugs provides comprehensive guidance to the pharmacological properties of drugs used to treat gastrointestinal conditions, including mechanisms of action, appropriate administration, and potential adverse effects associated with their use.

Organized by class of drug and ranging from PPIs to immunosupressants, each chapter first examines the specific agents within that class and then their appropriate and judicious use across a range of specific GI disorders.

Key features include:

• Introduction of drug class
• Basic pharmacology, including mechanism of action, bioavailability, metabolism, interactions, adverse effects, toxicity, and special considerations
• Dosing information for each GI condition and on- and off-label use
• Consistent use of both generic and trade names throughout
• Specific reference to drug use in pediatric patients and during pregnancy

Perfect for quick consultation on the wards and in the office, Pocket Guide to Gastrointestinal Drugs is the ideal tool for all those managing patients with GI conditions, including gastroenterologists, GI trainees, emergency physicians, GI specialist nurses, primary care physicians and residents, intensivists and pharmacists.

Table Of Contents:

• List of contributors, xi
• Preface, xvi
• PART I: UPPER GI TRACT
• 1 Prokinetic agents and antiemetics, 3
• Hemangi Kale and Ronnie Fass
• Prokinetics, 3
• Antiemetic agents, 7
• Recommended reading, 14
• 2 Proton pump inhibitors, 15
• Wanda P. Blanton and M. Michael Wolfe
• Introduction, 15
• Mechanism of action, pharmacodynamics, kinetics, 15
• Clinical use and dosing, 18
• Adverse effects/safety, 27
• Recommended reading, 28
• 3 Histamine H2-receptor antagonists, 31
• Kentaro Sugano
• Introduction, 31
• Mechanism of action, 31
• Pharmacology, 33
• Clinical effectiveness, 40
• Adverse events, 41
• Recommended reading, 42
• 4 Prostaglandins and other mucosal protecting agents, 44
• Carlos Sostres and Angel Lanas
• Introduction of drug class, 44
• Physicochemical properties, 45
• Formulations and recommended dosages, 46
• Mechanism of action, 47
• Drug interactions, 48
• Pharmacokinetics, 49
• Clinical effectiveness, 49
• Toxicity, 51
• Pregnancy classes, 52
• Other mucosal protecting agents, 52
• Recommended reading, 54
• PART II: SMALL AND LARGE INTESTINE
• 5 5-HT modulators and other antidiarrheal agents and cathartics, 59
• Albena Halpert and Douglas Drossman
• Introduction, 59
• 5-HT modulators used in the management of GI disorders, 59
• 5-HT agents approved in the US for specific GI indications, 60
• Medications used for the treatment of chronic constipation, 71
• Medications used for the treatment of narcotic-induced constipation, 76
• Antidiarrheal agents, 76
• Conclusion, 80
• Recommended reading, 80
• 6 5-aminosalicylates, 82
• Hannah L. Miller and Francis A. Farraye
• Introduction, 82
• Preparations, 82
• Clinical use and efficacy, 84
• Pharmacology: preparations and dosing, 87
• Mechanism of action, 89
• Bioavailability and metabolism, 89
• Adverse effects and toxicity, 91
• Pregnancy, 93
• Drug interactions (package inserts), 94
• Precautions and contraindications, 94
• Special considerations: effectiveness in colorectal cancer prevention, 96
• Conclusion, 97
• Recommended reading, 97
• 7 Immunosuppressive agents, 100
• Lev Lichtenstein and Gerald M. Fraser
• Introduction, 100
• Thiopurines, 100
• Low-dose methotrexate (MTX), 106
• Calcineurin inhibitors, 111
• Recommended reading, 114
• 8 Biological agents, 117
• Gert Van Assche
• Biological agents approved to treat IBD, 117
• Optimal treatment strategies with anti TNF therapies in IBD, 119
• Safety of biological agents in IBD, 120
• Emerging biologicals, 121
• Recommended reading, 121
• PART III: LIVER AND PANCREAS
• 9 Interferons, 125
• Robert C. Lowe
• Introduction, 125
• Mechanism of action, 125
• Pharmacology, 126
• Clinical effectiveness, 127
• Toxicity, 128
• Interferon types with generic and brand names, 129
• Pregnancy classes, 130
• Initial interferon dosing regimens for chronic hepatitis C, 130
• Recommended reading, 131
• 10 Nucleoside analogs, 133
• Uri Avissar and David P. Nunes
• Introduction, 133
• Mechanism of action, 135
• Pharmacology, 137
• Clinical effectiveness, 139
• Nucleoside analogs, 141
• Nucleotide analogs, 146
• Summary, 147
• Recommended reading, 148
• 11 Ursodeoxycholic acid, chelating agents, and zinc in the treatment of metabolic liver diseases, 150
• Andrew K. Burroughs and James S. Dooley
• Ursodeoxycholic acid, 150
• Treatment of copper overload, 155
• Recommended reading, 162
• 12 Agents for the treatment of portal hypertension, 165
• Karen L. Krok and Andrés Cárdenas
• Introduction, 165
• Nonselective beta-blockers (NSBB), 166
• Nitrates, 169
• Vasopressin analogs, 169
• Somatostatin analog, 170
• Midodrine, 171
• Albumin, 172
• Loop diuretics, 172
• Aldosterone antagonist, 174
• Aquaretics, 174
• Disaccharides, 175
• Antibiotics, 176
• Recommended reading, 177
• 13 Pancreatic enzymes, 179
• Steven J. Czinn and Samra S. Blanchard
• Introduction, 179
• Mechanism of action, 180
• Dosing and schedule of administration, 180
• Monitoring therapy, 183
• Adverse effects, 183
• Recommended reading, 184
• PART IV: ANTIMICROBIALS AND VACCINES
• 14 Antibiotics for the therapy of gastrointestinal diseases, 187
• Melissa Osborn
• Introduction, 187
• Pharmacologic properties, 187
• Clinical uses, 195
• Recommended reading, 202
• 15 Antimicrobials for parasitic diseases, 204
• Joachim Richter
• 5-Nitroimidazoles, 204
• Benzimidazoles, 206
• Ivermectin, 211
• Praziquantel, 212
• Treatment dosages, 214
• Recommended reading, 216
• 16 Vaccines for viral hepatitides, 219
• Savio John and Raymond T. Chung
• Hepatitis A vaccination, 219
• Hepatitis B vaccination, 222
• Recommended reading, 227
• 17 Rotavirus and other enteric vaccinations, 229
• Christopher J. Moran and Esther J. Israel
• Rotavirus vaccination, 229
• Typhoid fever vaccination, 232
• Recommended reading, 233
• PART V: NUTRITION AND PROBIOTICS
• 18 Parenteral and enteral nutrition feeding formulas, 237
• Dominic N. Reeds and Beth Taylor
• Introduction, 237
• Indications for nutrition support, 237
• Energy and macronutrient requirements, 237
• Protein, 238
• Carbohydrate, 239
• Lipids, 239
• Enteral liquid feeding formulations, 239
• Disease-specifi c formulas, 244
• Selection of an appropriate enteral formula, 245
• Implementation of enteral nutrition, 245
• Parenteral nutrition, 245
• Summary, 247
• Recommended reading, 247
• 19 Probiotics, 249
• Christina M. Surawicz
• Introduction, 249
• Pharmacology, 250
• Mechanisms of action, 251
• Clinical indications, 251
• Safety/toxicity, 255
• Summary, 255
• Recommended reading, 256
• Index, 259

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