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Drug Delivery Applications of Noninvasive Imaging - Chun Li / Mei Tian
Drug Delivery Applications of Noninvasive Imaging - Chun Li / Mei Tian
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Author : Chun Li / Mei Tian Language: English Finishing : Hardcover, 494 pages ISBN : 978-0-470-63347-2 Edition Number: 2013 Description: Cost-effective strategies for designing novel drug delivery systems that target a broad range of disease conditions In vivo imaging has become an important tool for the development of new drug delivery systems, shedding new light on...
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Descripción completa de: Drug Delivery Applications of Noninvasive Imaging - Chun Li / Mei Tian
Author : Chun Li / Mei Tian
Language: English
Finishing : Hardcover, 494 pages
ISBN : 978-0-470-63347-2
Edition Number: 2013
Description:
Cost-effective strategies for designing novel drug delivery systems that target a broad range of disease conditions
In vivo imaging has become an important tool for the development of new drug delivery systems, shedding new light on the pharmacokinetics, biodistribution, bioavailability, local concentration, and clearance of drug substances for the treatment of human disease, most notably cancer. Written by a team of international experts, this book examines the use of quantitative imaging techniques in designing and evaluating novel drug delivery systems and applications.
Drug Delivery Applications of Noninvasive Imaging offers a full arsenal of tested and proven methods, practices and guidance, enabling readers to overcome the many challenges in creating successful new drug delivery systems. The book begins with an introduction to molecular imaging. Next, it covers:
- In vivo imaging techniques and quantitative analysis
- Imaging drugs and drug carriers at the site of action, including low-molecular weight radiopharmaceuticals, peptides and proteins, siRNA, cells, and nanoparticles
- Applications of imaging techniques in administration routes other than intravenous injection, such as pulmonary and oral delivery
- Translational research leading to clinical applications
- Imaging drug delivery in large animal models
- Clinical applications of imaging techniques to guide drug development and drug delivery
Chapters are based on a thorough review of the current literature as well as the authors' firsthand experience working with imaging techniques for the development of novel drug delivery systems.
Presenting state-of-the-technology applications of imaging in preclinical and clinical evaluation of drug delivery systems, Drug Delivery Applications of Noninvasive Imaging offers cost-effective strategies to pharmaceutical researchers and students for developing drug delivery systems that accurately target a broad range of disease conditions.
Table Of Contents:
- Preface ix
- contributors xi
- 1 Introduction to Molecular Imaging 1
- Vikas Kundra
- 2 PET/SPECT: Instrumentation and Imaging Techniques 12
- Yuan-Chuan Tai
- 3 Photoacoustic Tomography and Its Applications in Drug Delivery and Photothermal Therapy 45
- Liang Song and Lihong V. Wang
- 4 Raman Microspectral Imaging for Label-Free Detection of Nanoparticle-Mediated Cellular and Subcellular Drug Delivery 70
- Tatyana Chernenko, Lara Milane, Christian Matthäus, Max Diem, and Mansoor Amiji
- 5 A natomical and Functional MRI91
- Edward F. Jackson
- 6 Quantitative Imaging in Drug Delivery 125
- Kooresh I. Shoghi
- 7 PET Imaging of the Pharmacokinetics of Small Molecular-Weight Drugs 147
- Stephen M. Moerlein and Zhude Tu
- 8 Imaging Peptides, Proteins, and Antibody Delivery 192
- Frederik L. Giesel and Clemens Kratochwil
- 9 In Vivo Imaging and Delivery of siRNA199
- Zdravka Medarova and Anna Moore
- 10 Imaging Cell Therapy 223
- Yajie Liang and Jeff W. M. Bulte
- 11 Radiolabeled Liposomes as Drug Delivery Nanotheranostics 252
- William T. Phillips, Ande Bao, Keitaro Sou, Shihong Li, and Beth Goins
- 12 Polymeric Micelles as Imaging Agents and Drug Delivery Systems 268
- Jun Zhao and Chun Li
- 13 Perfluorocarbon Nanoparticles: Translating Bench Opportunities to the Clinic 296
- G. M. Lanza, P. M. Winter, S. D. Caruthers, A. H. Schmieder, and S. A. Wickline
- 14 Cancer Theranostics with Hollow Gold Nanospheres 308
- Wei Lu and Chun Li
- 15 Imaging Pulmonary Drug Delivery 333
- Stephen P. Newman
- 16 In Vivo Imaging for Validation of Oral Dose Performance 367
- Fiona J. McInnes and Howard N. E. Stevens
- 17 Role of Large Animal Models in Translational Studies of Imaging and Targeted Drug Delivery 389
- Rajesh K. Uthamanthil and Mei Tian
- 18 Imaging Transcatheter Delivery to Liver Tumors 412
- Adil Al-Nahhas, Meeran Naji, and Imene Zerizer
- 19 Direct Visualization of Therapeutic Radionuclide Distribution Using Nuclear Medicine Imaging: I-131 in Metastatic Thyroid Carcinoma 426
- Ho Young Lee, June-Key Chung, So Won Oh, Jong Jin Lee, Keon Wook Kang, Do Joon Park, Bo Youn Cho, and Myung Chul Lee
- 20 Imaging Drug Delivery to the CNS Using Translational Positron Emission Tomography Studies 432
- Chi-Ming Lee, Katarina Varnäs, and Lars Farde
- Index 449
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