Stem Cell Therapeutics for Cancer - Khalid Shah
Descripción
Autor: Khalid Shah Encuadernación: 304 págs Idioma: English Referencia: 978-1-118-28242-7 Nº Edición: 2013 Contenido: Stem Cell Therapeutics for Cancer covers the application of stem cells in various cancers, with an emphasis on the aspects of these strategies that are critical to the success of future stem cell-based therapies for cancer. Topics covered in the book include...
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Descripción completa de: Stem Cell Therapeutics for Cancer - Khalid Shah
Autor: Khalid Shah
Encuadernación: 304 págs
Idioma: English
Referencia: 978-1-118-28242-7
Nº Edición: 2013
Contenido:
Stem Cell Therapeutics for Cancer covers the application of stem cells in various cancers, with an emphasis on the aspects of these strategies that are critical to the success of future stem cell-based therapies for cancer. Topics covered in the book include stem cell sources, tumor specificity, targeted therapeutics, visualizing the stem cell, and therapeutic agent pharmacokinetics. Each chapter contains a brief introduction to the cancer, followed by an exploration of how engineered stem cells have been utilized to cure the disease in mouse models and in early phase clinical trials.
- Comprises of sections on stem cell therapy in brain cancers, lung cancers, breast cancers, as well as stem cells in combination with other therapies
- Focuses on the practical applications of using stem cells as gene delivery agents to treat cancer
- Includes coverage of cutting-edge molecular imaging techniques in stem cell therapeutics for a variety of tumour types
Tabla de Contenidos:
- Contributors vii
- Preface xi
Section 1 Introduction 1
- 1 Stem Cell Sources and Their Potential for Cancer Therapeutics 3
- Khalid Shah
Section 2 Migration and Fate of Stem Cells 11
- 2 The Role of CXCR4 as a Mediator of Glioma-Tropic Neural Precursor Cell Migration 13
- Moneeb Ehtesham, Elliot Min, and Rebecca Kasl
- 3 Tumor Tropism of Mesenchymal Stem Cells 21
- Paula Y. P. Lam and Ivy A.W. Ho
Section 3 Stem Cell Therapy in Brain Cancer 39
- 4 Stem Cell-Mediated Trail Therapy for Highly Aggressive Brain Tumors 41
- Khalid Shah
- 5 Stem Cell-Mediated Prodrug Gene Therapy of High-Grade Brain Tumors 57
- Cestmir Altaner
- 6 Role of Naïve Cord Blood Stem Cells in Glioma Therapy 73
- Venkata Ramesh Dasari, Kiran Kumar Velpula, and Jasti S. Rao
- 7 Stem Cell-Based Antiangiogenic Therapies for Brain Tumors 87
- Navid Redjal and Khalid Shah
- 8 Treatment of Metastatic Neuroblastoma with Mesenchymal Stem Cell-Based Oncolytic Virotherapy 103
- Manuel Ramírez and Javier García-Castro
- Section 4 Stem Cell Therapy in Other Cancer Types 111
- 9 Umbilical Cord Matrix Stem Cells for Cytotherapy of Breast Cancer 113
- Naomi Ohta, Atsushi Kawabata, Deepthi Uppalapati, Susumu Ishiguro, Deryl Troyer, and Masaaki Tamura
- 10 Mesenchymal Stromal Cells as Effective Tumor Antigen-Presenting Cells in Cancer Therapeutics 127
- Raphaëlle Romieu-Mourez and Jacques Galipeau
- 11 Diagnostic and Therapeutic Mesenchymal Stem Cells for Breast Cancer Treatment 145
- Róisín Dwyer
- 12 Genetically Engineered Stem Cell Therapies Targeting Gastrointestinal Malignancy 159
- Emily Keung, Peter J. Nelson, and Claudius Conrad
- 13 Mesenchymal Stem Cells in Prostate Cancer: Clinical Opportunities 171
- Diptiman Chanda and Selvarangan Ponnazhagan
- 14 Primed Mesenchymal Stromal Cells for Cancer Therapy 187
- Augusto Pessina, Arianna Bonomi, Eugenio Parati, Roberto Pallini, and Giulio Alessandri
Section 5 Combinatorial Stem Cell Therapies 203
- 15 MicroRNA Adjuvants in Stem Cell-Based Cancer Therapy 205
- Maarten C. J. Anderegg and Maarten F. Corsten
- 16 Stem Cell-Based Combination Therapies for Cancer: Systemic Delivery of a PI3K/mTOR Inhibitor (PI-103) and Stem Cell-Mediated Delivery of TRAIL in Brain Tumors 219
- Tugba Bagci-Onder
- 17 The Efficacy of Clinically Approved Agents with Stem Cell-Delivered Therapeutics for Cancer Therapy 235
- Hiroaki Wakimoto and Khalid Shah
Section 6 Tracking Stem Cells and Stem Cell-Based Therapeutics 245
- 18 Imaging Migration and Fate of Stem Cells in Experimental Models of Cancer 247
- Deepak Bhere and Khalid Shah
- 19 Multifunctional Molecules for Interrogating Stem Cell-Based Therapeutics 257
- Shawn Hingtgen
- 20 Tracking Cancer-Targeted MSC with PET Imaging 273
- Véronique Roelants and Jean-Louis Vanoverschelde
- Index 289
- Color plate is located between pages 244 and 245.
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