Author: Hannu Larjava 

Language: English

Finishing: Hardcover, 424 pages

ISBN:  978-0-8138-0481-1

Edition: 1/2012

ORAL WOUND HEALING CELL BIOLOGY AND CLINICAL MANAGEMENT

Hannu Larjava 

Author Information

Hannu Larjava, DDS, PhD, DipPerio is Professor and Chair of the Division of Periodontics at the University of British Columbia Faculty of Dentist

Description

Oral Wound Healing: Cell Biology and Clinical Management brings experts from around the world together to provide an authoritative reference on the processes, principles and clinical management of wound healing in the oral mucosa. Promoting a thorough understanding of current research on the topic, this new resource draws together thinking on the basic biological processes of wound healing in the oral environment, as well as providing more detailed information and discussion on processes such as inflammation, reepithelialization and angiogenesis. Beyond this, the book goes on to examine topics pertinent to the effective clinical management of oral wound healing, bringing together chapters on large dento-facial defects, dental implants, periodontal regeneration, and pulp healing.An essential synthesis of current research and clinical applications, Oral Wound Healing will be an indispensable resource for dental specialists, oral and maxillofacial surgeons as well as researchers in oral medicine and biology.

Table of Contents

• Contributors
• Preface

1. Oral Wound Healing: An Overview 
   Hannu Larjava
• Clotting and inflammation (chapters 2, 3 and 4)
• Re-epithelialization and granulation tissue formation (chapters 5 and 6)
• Angiogenesis (chapter 7)
• Healing of extraction sockets (chapter 8)
• Flap design for periodontal wound healing (chapter 9)
• Regeneration of periodontal tissues (chapters 10 and 11)
• Osteointegration and soft tissue healing around dental implants (chapter 12)
• The pulp healing process (chapter 13)
• Dermal wound healing and burn wounds (chapter 14)
• Healing of large dentofacial defects (chapter 15)
• References
2. Hemostasis, Coagulation and Complications 
   Carol Oakley and Hannu Larjava
• Introduction
• Primary hemostasis
• Secondary hemostasis and the coagulation system
• Tertiary hemostasis
• Tissue factor
• Von willebrand factor
• Other coagulation factors
• Cell-centric model of hemostasis: from initiation to propagation
• The procoagulant membrane
• Membrane particles
• Endothelium and hemostasis
• Pro- and anticoagulant functions
• Platelets
• Coagulation and wound healing
• Limitations of the waterfall cascade model and screening laboratory tests
• Implications for laboratory tests
• Pre-surgical evaluation to prevent bleeding problems
• Conclusions
• References
3. Inflammation and Wound Healing 
   Anna Turabelidze and Luisa Ann DiPietro
• Introduction
• The innate immune response in wounds
• Inflammatory cell infiltration into wounds
• Inflammatory cell function in wounds
• Cytokines and chemokines in wounds
• Inflammation in oral mucosal wounds
• Inflammation in fetal wounds
• Role of inflammation in keloids
• Inflammation and diabetic wounds
• Conclusions
• References
4. Specialized Pro-resolving Lipid Derived Fatty Acid Mediators: Wiring the Circuitry of Effector Immune Homeostasis 
   Gabrielle Fredman and Charles N. Serhan
• Inflammation: the cardinal signs
• Complete resolution and tissue homeostasis is the ideal outcome of acute inflammation
• Lipoxins, resolvins, protectins and maresins: semper vigilantes of anti-inflammation and pro-resolution
• Resolution of inflammation is an actively regulated process in vivo
• Resolvins and protectins are protective in experimental models of inflammatory diseases
• Specialized pro-resolving lipid mediators in oral medicine: restoration of tissue homeostasis in experimental periodontitis
• Resolution and wound healing
• Anti-inflammation vs. Pro-resolution
• Clinical implications and the development of stable analogs
• Conclusions
• Acknowledgments
• References
5. Re-epithelialization of Wounds 
   Leeni Koivisto, Lari Häkkinen and Hannu Larjava
• Introduction
• Keratinocytes form a protective barrier between an organism and its environment
• Keratinocytes are activated rapidly to restore the epithelial barrier after wounding
• Many different factors contribute to re-epithelialization
• Final stages of re-epithelialization
• Failure to re-epithelialize: chronic wounds
• Conclusions
• References
6. Granulation Tissue Formation and Remodeling 
   Lari Häkkinen, Hannu Larjava and Leeni Koivisto
• Introduction
• Overview of connective tissue response to wounding
• Wound healing stages
• Origin and identity of wound fibroblasts
• Granulation tissue formation
• Connective tissue remodeling
• Re-emergence of quiescent fibroblast phenotype
• Specific features of oral mucosal wound healing
• Conclusions
• Acknowledgments
• References
7. Angiogenesis and Wound Healing: Basic Discoveries, Clinical Implications and Therapeutic Opportunities 
   Peter J. Polverini
• Introduction
• How blood vessels develop
• Early mechanistic insights into the angiogenic response: from solid tumors to chronic inflammation and wound healing
• The role of other inflammatory cells in angiogenesis
• Matrix molecules
• Vascular endothelial growth factor and the modern era of angiogenesis research
• Signaling networks of potential importance in wound neovascularization
• Inhibitors of angiogenesis: important counterweights in wound neovascularization
• The role of aberrant wound angiogenesis in the pathogenesis of diabetes mellitus
• Conclusions
• References
8. Wound Healing of Extraction Sockets 
   Roberto Farina and Leonardo Trombelli
• Healing of extraction sockets
• Factors influencing the healing of extraction sockets
• Healing of extraction sockets following immediate implant placement
• Does the use of reconstructive technologies alter the healing of extraction sockets?
• Conclusions
• References
9. Flap Designs for Periodontal Healing 
   Leonardo Trombelli and Roberto Farina
• Flap management, wound stability and periodontal regeneration
• Flap designs to achieve primary closure
• Surgical treatment of periodontal intraosseous defects: technical hints
• Conclusions
• References
10. Periodontal Regeneration: Experimental Observations – Clinical Consequences 
    Ulf M.E. Wikesjö, Cristiano Susin, Jaebum Lee, Douglas P. Dickinson and Giuseppe Polimeni
• Introduction
• Wound healing
• Periodontal wound healing
• Periodontal regeneration – new attachment
• Wound stability
• Space provision
• Wound closure for primary intention healing
• Conclusions
• Acknowledgment
• References
11. Biological Agents and Cell Therapies in Periodontal Regeneration 
    Hannu Larjava, Yi Yang, Edward Putnins, Jyrki Heino and Lari Häkkinen
• Introduction
• Adjunct growth factors in periodontal wound repair
• PDGF and IGF-1 in periodontal regeneration
• Platelet-rich plasma in periodontal therapy
• FGF-2 in periodontal regeneration
• Growth and differentiation factor-5 in periodontal regeneration
• Other growth factors in periodontal regeneration
• Bioactive collagen-derived peptide in periodontal regeneration (PepGen P-15®)
• Enamel matrix proteins in periodontal regeneration and wound healing
• Stem cells in periodontal wound healing
• Conclusions
• References
12. Wound Healing Around Dental Implants 
    Cristina Cunha Villar, Guy Huynh-Ba, Michael P. Mills and David L. Cochran
• Introduction
• Historical development
• Titanium – the metal of choice
• Healing following implant placement
• Peri-implant soft tissue healing
• Implant/peri-implant mucosa interface
• Peri-implant hard tissue healing
• From healing to clinical application
• Implant stability testing
• Wound healing and loading protocols
• Conclusions
• References
13. The Pulp Healing Process: From Generation to Regeneration 
    Stéphane Simon, Anthony J. Smith, Philip J. Lumley, Paul R. Cooper, and Ariane Berdal
• From generation to regeneration
• At the molecular level
• Conclusion
• References
14. Dermal Wound Healing and Burn Wounds 
    Anthony Papp
• Introduction
• Burn injury
• Skin anatomy
• Burn depth
• Wound healing
• Treatment
• Special features in perioral burns
• Conclusions
• References
15. Healing of Large Dentofacial Defects 
    George K.B. Sándor, Robert P. Carmichael, Leena P. Ylikontiola, Ahmed Jan, Marc G. DuVal and Cameron M.L. Clokie
• Introduction
• The need for bone
• Bone healing
• Surgical maneuvers to induce and promote healing of large defects
• Specifically difficult wounds
• Conclusions
• References

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