Librería Servicio Médico

Author : Jager / Koch / Flohe / M. Selzer

Language: English

Finishing : Hardcover, 576 pages

ISBN : 978-3-527-33255-7

Edition Number: 2013

Description:

This is the first resource to provide researchers in academia and industry with an urgently needed update on drug intervention against trypanosomatides. As such, it
covers every aspect of the topic from basic research findings, via current treatments to translational approaches in drug development and includes both human and livestock diseases. The outstanding editor and contributor team reads like a Who?s Who of the field, thus guaranteeing the outstanding quality of this ready reference.

Table Of Contents:

• Foreword IX
• Acknowledgment XV
• Preface XVII
• List of Contributors XIX

Part One Disease Burden, Current Treatments, Medical Needs, and Strategic Approaches 1

• 1 Visceral Leishmaniasis – Current Treatments and Needs 3
• Poonam Salotra, Ruchi Singh, and Karin Seifert
• 2 Chemotherapy of Leishmaniasis: A Veterinary Perspective 17
• María Jesus Corral-Caridad and Jose María Alunda
• 3 Pharmacological Metabolomics in Trypanosomes 37
• Darren J. Creek, Isabel M. Vincent, and Michael P. Barrett
• 4 Drug Design and Screening by In Silico Approaches 57
• Mattia Mori and Maurizio Botta
• 5 Computational Approaches and Collaborative Drug Discovery for Trypanosomal Diseases 81
• Sean Ekins and Barry A. Bunin

Part Two Metabolic Peculiarities in the Trypanosomatid Family Guiding Drug Discovery 103

• 6 Interaction of Leishmania Parasites with Host Cells and its Functional Consequences 105
• Uta Schurigt, Anita Masic, and Heidrun Moll
• 7 Function of Glycosomes in the Metabolism of Trypanosomatid Parasites and the Promise of Glycosomal Proteins as Drug Targets 121
• Melisa Gualdron-Lopez, Paul A.M. Michels, Wilfredo Qui~nones, Ana J. Caceres, Luisana Avilan, and Juan-Luis Concepcion
• 8 Glyoxalase Enzymes in Trypanosomatids 153
• Marta Sousa Silva, Antonio E.N. Ferreira, Ricardo Gomes, Ana M. Tomas,
• Ana Ponces Freire, and Carlos Cordeiro
• 9 Trypanothione-Based Redox Metabolism of Trypanosomatids 167
• Marcelo A. Comini and Leopold Flohe
• 10 Thiol Peroxidases of Trypanosomatids 201
• Helena Castro and Ana M. Tomas
• 11 Peroxynitrite as a Cytotoxic Effector Against Trypanosoma cruzi: Oxidative Killing and Antioxidant Resistance Mechanisms 215
• Madia Trujillo, María Noel Alvarez, Lucía Piacenza, Martín Hugo, Gonzalo Peluffo, and Rafael Radi
• 12 Selenoproteome of Kinetoplastids 237
• Alexei V. Lobanov and Vadim N. Gladyshev
• 13 Replication Machinery of Kinetoplast DNA 243
• Rachel Bezalel-Buch, Nurit Yaffe, and Joseph Shlomai
• 14 Life and Death of Trypanosoma brucei: New Perspectives for DrugDevelopment 261
• Torsten Barth, Jasmin Stein, Stefan Mogk, Caroline Sch€onfeld, Bruno K. Kubata, and Michael Duszenko

Part Three Validation and Selection of Drug Targets in Kinetoplasts 279

• 15 Rational Selection of Anti-Microbial Drug Targets: Unique or Conserved? 281
• Boris Rodenko and Harry P. de Koning
• 16 Drug Targets in Trypanosomal and Leishmanial Pentose Phosphate Pathway 297
• Marcelo A. Comini, Cecilia Ortíz, and Juan Jose Cazzulo
• 17 GDP-Mannose: A Key Point for Target Identification and Drug Design in Kinetoplastids 315
• Sebastien Pomel and Philippe M. Loiseau
• 18 Transporters in Anti-Parasitic Drug Development and Resistance 335
• Vincent Delespaux and Harry P. de Koning
• 19 Peptidases in Autophagy are Therapeutic Targets for Leishmaniasis 351
• Roderick A.M. Williams
• 20 Proteases of Trypanosoma brucei 365
• Dietmar Steverding

Part Four Examples of Target-Based Approaches and Compounds Under Consideration 383

• 21 Screening Approaches Towards Trypanothione Reductase 385
• Mathias Beig, Frank Oellien, R. Luise Krauth-Siegel, and Paul M. Selzer
• 22 Redox-Active Agents in Reactions Involving the Trypanothione/Trypanothione Reductase-based System to Fight Kinetoplastidal Parasites 405
• Thibault Gendron, Don Antoine Lanfranchi, and Elisabeth Davioud-Charvet
• 23 Inhibition of Trypanothione Synthetase as a Therapeutic Concept 429
• Oliver Koch, Timo J€ager, Leopold Flohe, and Paul M. Selzer
• 24 Targeting the Trypanosomatidic Enzymes Pteridine Reductase and Dihydrofolate Reductase 445
• Stefania Ferrari, Valeria Losasso, Puneet Saxena, and Maria Paola Costi
• 25 Contribution to New Therapies for Chagas Disease 473
• Patricia S. Doyle and Juan C. Engel
• 26 Ergosterol Biosynthesis for the Specific Treatment of Chagas Disease: From Basic Science to Clinical Trials 489
• Julio A. Urbina
• 27 New Developments in the Treatment of Late-Stage Human African Trypanosomiasis 515
• Cyrus J. Bacchi, Robert T. Jacobs, and Nigel Yarlett
• Index 531

Valoración:

¡Sea el primero en dejar un comentario!

Nuevo Comentario