Librería Servicio Médico

Author : Doerig / Spaeth / Wiese / M. Selzer

Language: English

Finishing : Hardcover, 456 pages

ISBN : 978-3-527-33235-9

Edition Number: 2013

Description:

This is the first book to collect and summarize in one publication the efforts to use kinases or phosphatases for drug development against parasite infections. 
The editors and contributors comprise the Who is Who in the field, and they are comprehensive in covering every aspect of the topic, from basic research findings to translational approaches in drug development
The result will be welcomed by everyone in academia and industry participating in the global effort to finally combat the major diseases caused by eukaryotic parasites. This is volume one of a two-volume treatise, the second being exclusively dedicated to efforts to combat malaria using the same approach. 

Table Of Contents:

• Foreword VII
• Preface XI
• List of Contributors XV

Part One Bioinformatics 1

• 1 Computational Analysis of Apicomplexan Kinomes 3
• Eric Talevich, Natarajan Kannan, and Diego Miranda-Saavedra
• 2 Phosphatomes of Unicellular Eukaryotic Parasites 37
• Alexandra V. Andreeva and Mikhail A. Kutuzov

Part Two Functional Analysis of Parasite Kinomes and Phosphatomes 61

• 3 Trypanosomatid Phosphoproteomics 63
• Michael D. Urbaniak
• 4 Trypanosomatid Cell Division Kinases 79
• Corinna Benz, Elizabeth Thomas, and Tansy C. Hammarton
• 5 Kinetoplastid AGC Kinases 99
• Sabine Bachmaier and Michael Boshart
• 6 Plasmodium eIF2a Kinases 123
• Daniel E. Goldberg, Min Zhang, and Victor Nussenzweig
• 7 Protein Kinases of the Parasitic Protist Entamoeba histolytica 131
• Somlata, Mrigya Babuta, Sudha Bhattacharya, and Alok Bhattachary
• 8 Protein Phosphatases in Trypanosome Growth and Development 155
• Balazs Szoor and Keith R. Matthews

Part Three Role of Host Cell Kinomes and Phosphatomes in Parasitic Infections 179

• 9 Hijacking of Host Cell Signaling by Theileria 181
• Kerry Woods, Conrad von Schubert, and Dirk Dobbelaere
• 10 The Role of Host- and Parasite-Encoded Kinases in Toxoplasma–Host Interactions 199
• Ira J. Blader, Gustavo Arrizabalaga, and William J. Sullivan Jr
• 11 Macrophage Kinases in Leishmaniasis 217
• Mahesh Kumar Padwal, Uddipan Sarma, Raki Sudan, and Bhaskar Saha

Part Four Drug Discovery 235

• 12 Selective Inhibition of Parasite Protein Kinases 237
• Jennifer D. Artz, Amy K. Wernimont, Linda. Y. Lin, Merhnaz Amani, Mirela Neculai, Tanya Hills, and Raymond Hui
• 13 Kinase Inhibitors Among Hits from Malaria Cellular Screens 261
• James R. Brown, David Drewry, Francisco-Javier Gamo, and Jose F. Garcia-Bustos
• 14 Calcium-Dependent Protein Kinases of Apicomplexan Parasites as Drug
• Targets 293
• Kayode K. Ojo, Ethan A. Merritt, Dustin J. Maly, and Wesley C. Van Voorhis
• 15 Protein Kinases as Suitable Targets for Combating Eimeria spp. 317
• Richard J. Marh€ofer, Jeremy C. Mottram, and Paul M. Selzer
• 16 Receptor Tyrosine Kinase Signaling and Drug Targeting in Schistosomes 337
• Colette Dissous, Mathieu Vanderstraete, Svenja Beckmann, Nadege Gouignard, Silke Leutner, Christin Buro, and Christoph G. Grevelding
• 17 Protein Kinases as Drug Targets in the Treatment of Alveolar Echinococcosis 357
• Klaus Brehm
• 18 Collaborative Drug Design of Plasmodium Kinase Inhibitors 375
• Barry Hardy, Roman Affentranger, Alessandro Contini, Hugo Gutierrez de Teran, Jeff Spitzner, Ruben Papoian, William L. Seibel, Sandra Nelson, Jeffrey Wiseman, Sharon D. Bryant, Isabelle Lucet, and Christian Doerig
• Index 417

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