Author: M. Fribley, Andrew (Ed.)

Language: English

Finishing: Hardcover

ISBN: 9783319276458

TARGETING ORAL CANCER

M. Fribley, Andrew (Ed.)

Description:

This book provides research-oriented care providers with up-to-date information on the oral cancer patient population, the ways in which we are treating them, and the scientific approaches being pursued in order to improve survival and reduce treatment-related morbidity. The text is organized into three sections covering epidemiology and management, cancer development and biomarkers, and breaking developments and novel approaches for drug discovery. The first section includes discussion of the emerging role of HPV in oral cancer and explains the surgical, chemotherapy and radiation approaches to treatment. Aspects such as molecular progression, the role of cancer stem cells in tumor development, and the value of various biomarkers are then examined. The final section is devoted to the latest advances and covers, among other topics, current clinical trials, emerging drug targets, and targeting of the unfolded protein response and of mediators of coagulation.

Table of contents:

1. Assessing the Changing Oral and Pharyngeal Cancer Demographic in the United States

2. The Emerging Role of HPV in Head and Neck Cancer

3. Oral Cancer: Location, Staging, Surgical Management, and Outcomes

4. Chemotherapy in Head and Neck Squamous Cell Cancer

   Molecular Signaling in Oral Cancer Invasion and Metastasis

5. Chang, Insoon (et al.)

6. Cancer Stem Cells in the Biology and Treatment of Head and Neck Squamous Cell Carcinoma

7. HNSCC Biomarkers Derived from Key Processes of Cancerogenesis

8. Emerging Molecular Targets in the Treatment of Head and Neck Squamous Cell Carcinoma

9. Immunotherapy in Head and Neck Cancers

10. The Unfolded Protein Response as a Therapeutic Target for Head and Neck Squamous Cell Carcinoma

11. Targeting Coagulation Mediators in Head and Neck Cancer

12. Mucosal Therapy for Potentially Malignant Diseases and OSCC

Authors:

Andrew M. Fribley graduated with a BS from Central Michigan University, Mt. Pleasant, MI and in 2005 gained his PhD from the University of Michigan, Ann Arbor, MI (Program in Oral Health Sciences, University of Michigan School of Dentistry). He then worked as a Post-Doctoral Research Fellow in the University of Michigan, School of Medicine, Department of Biological Chemistry and the Howard Hughes Medical Institute In 2010, Dr. Fribley was appointed Assistant Professor of Pediatrics at Wayne State University (Division of Hematology/Oncology), Detroit, MI. He is also an Associate in the Department of Otolaryngology at Wayne State University and a Scientific Member of the Karmanos Cancer Institute (Molecular Therapeutics Program). Dr. Fribley has received various awards, including the William J. Gies Award for the most outstanding manuscript published in the Journal of Dental Research (2003) and the Edward Hatton Award (First Prize, Senior Category) from the American Association of Dental Research and the International Association of Dental Research (2004). Since 2012 he has been a member of the Fellowships Committee of the American Association of Dental Research. He has published original articles in a variety of leading peer-reviewed journals.

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