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Author: Sven Otto

Language: English

Finishing: Hardcover, 230 pages

ISBN: 9783662437322

Edition Number: 2015

Description:

Osteonecrosis of the jaws is a well-known side-effect of antiresorptive therapy that predominantly occurs in patients suffering from malignant diseases and receiving intravenous administrations of nitrogen-containing bisphosphonates or subcutaneous administrations of denosumab, a monoclonal antibody. Less frequently it may also be observed in patients with osteoporosis who are being treated with these antiresorptive drugs 

This textbook provides detailed, up-to-date information on all aspects of medication-related osteonecrosis of the jaws, including clinical features, pathogenesis, treatment options, and preventive measures. It also explains safe prevention and treatment strategies for patients receiving antiresorptive drugs who require extractions, implant insertions, and other dento-alveolar surgeries. This book will be of major interest for medical and dental students, dentists, and oral and maxillofacial surgeons as well as osteologists and oncologists.

Table of contents:

• Pharmacological Aspects of Antiresorptive Drugs: Bisphosphonates and Denosumab Bartl, Reiner (et al.)

  Bisphosphonate and Denosumab Therapy: Fields of Application Then, Cornelia (et al.)

• Risk Factors for Medication-Related Osteonecrosis of the Jaw Kwon, Tae-Geon

• Definition, Clinical Features and Staging of Medication-Related Osteonecrosis of the Jaw Otto, Sven (et al.)

• Epidemiology of Medication-Related Osteonecrosis of the Jaw Lazarovici, Towy Sorel (et al.)

• Imaging Modalities and Characteristics in Medication-Related Osteonecrosis of the Jaw Probst, Florian A. (et al.)

• Treatment of Medication-Related Osteonecrosis of the Jaw Pautke, Christoph

• Local and Microvascular Free Flaps in Patients with Medication-Related Osteonecrosis of the Jaw Mücke, Thomas (et al.)

• Adjuvant Treatment Options in the Management of Medication-Related Osteonecrosis of the Jaw Vescovi, Paolo (et al.)

• New and Innovative Treatment Strategies for Medication-Related Osteonecrosis of the Jaw Fliefel, Riham M. (et al.)

• Microbiology and Antibiotics in the Context of Medication-Related Osteonecrosis of the Jaw Hoefert, Sebastian

• Histopathology of Medication-Related Osteonecrosis of the Jaw Chaisuparat, Risa (et al.)

• Pathogenesis of Medication-Related Osteonecrosis of the Jaw Otto, Sven (et al.)

• Risk Reduction of Medication-Related Osteonecrosis of the Jaw Yarom, Noam (et al.)

• Animal Models of Medication-Related Osteonecrosis of the Jaw Allen, Matthew R.

• Dental Rehabilitation in Patients Receiving Antiresorptive Drugs Hoefert, Sebastian (et al.)

• Dental Implants in the Context Antiresorptive Drugs and Medication-Related Osteonecrosis of the Jaw Zebuhr, Yorck Alexander

• Osteonecrosis of the Jaw in Association with Targeted Therapy Troeltzsch, Matthias (et al.)

• History of Osteonecrosis of the Jaw Hoefert, Sebastian (et al.)

• Future Perspectives of Bisphosphonates in Maxillofacial, Dental, and Medical Practice Smeets, Ralf (et al.)

Author Information:

Sven Otto, MD, DDS, is a board-certified specialist in oral and maxillofacial surgery from Germany. He received both his dental degree (2002) and his medical degree (2006) from the University of Leipzig, Germany. Since 2006 he has been a resident at the Department of Oral and Maxillofacial Surgery, Ludwig-Maximilians University of Munich, Germany. One of his major fields of interest is bisphosphonate-related osteonecrosis of the jaw, especially the underlying pathophysiology. He has published numerous articles in leading scientific journals and has lectured nationally and internationally on this subject. In 2011, he was appointed group leader for “Jaw bone and osteonecrosis of the jaw” in the Laboratory for Experimental Surgery and Regenerative Medicine (ExperiMed) of the Ludwig-Maximilians University of Munich.

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